In type 1 diabetes, adding liraglutide to insulin increased hypoglycemia and hyperglycemia with ketosis.

Patients: 1398 patients 18 to 75 years of age (mean age 44 y, 52% women) who had type 1 diabetes for ≥ 12months treated with basal bolus or continuous subcutaneous insulin infusion for ≥ 6 months, stable insulin treatment for the past 3 months, bodymass index ≥ 20 kg/m, and hemoglobin (Hb) A1c levels 7.0% to 10% (53 to 86mmol/mol). Exclusion criteria included treatments that affect glycemic control, acute or chronic pancreatitis, estimated glomerular filtration rate < 30mL/min/1.73m, calcitonin level > 50 ng/L at baseline, personal or family history ofmedullary thyroid carcinomaor multiple endocrine neoplasia syndrome type2, or severe neuropathy.